Secretion of islet amyloid polypeptide in response to glucose

FEBS Letters

Yamaguchi, T.²  Tokuyama, Y.²  Yoshida, S.²  Adachi, M.¹  Kanatsuka, A.²  Makino, H.²  Ohsawa, H.² 

[1] Japan Immunoresearch Laboratories, Takasaki 370, Japan;Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

关键词: Islet amyloid polypeptide;    Pancreatic islet;    Secretion;    Radioimmunoassay;    IAPP;    islet amyloid polypeptide;    RIA;    radioimmunoassay;    HPLC;    high-performance liquid chromatography;   

DOI  :  10.1016/0014-5793(89)81527-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The content of isolet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.

【 授权许可】

Unknown