The Use of Simulated Body Fluid (SBF) for Assessing Materials Bioactivity in the Context of Tissue Engineering: Review and Challenges

Biomimetics

卷:5

Seiji Yamaguchi¹  Francesco Baino² 

[1] Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Aichi 487-8501, Japan;

[2] Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy;

关键词: bioactivity;    simulated body fluid (SBF);    biomaterials;    apatite;    bioactive glass;    titanium;   

DOI  :  10.3390/biomimetics5040057

来源: DOAJ

【 摘 要 】

Some special implantable materials are defined as “bioactive” if they can bond to living bone, forming a tight and chemically-stable interface. This property, which is inherent to some glass compositions, or can be induced by applying appropriate surface treatments on otherwise bio-inert metals, can be evaluated in vitro by immersion studies in simulated body fluid (SBF), mimicking the composition of human plasma. As a result, apatite coating may form on the material surface, and the presence of this bone-like “biomimetic skin” is considered predictive of bone-bonding ability in vivo. This review article summarizes the story and evolution of in vitro bioactivity testing methods using SBF, highlighting the influence of testing parameters (e.g., formulation and circulation of the solution) and material-related parameters (e.g., composition, geometry, texture). Suggestions for future methodological refinements are also provided at the end of the paper.

【 授权许可】

Unknown