Electrocatalytic C(sp3)–H/C(sp)–H cross-coupling in continuous flow through TEMPO/copper relay catalysis

Beilstein Journal of Organic Chemistry

卷:17

Bin Guo¹  Hai-Chao Xu¹ 

[1] Key Laboratory of Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering, Xiamen University, People’s Republic of China;

关键词: continuous flow;    copper;    catalysis;    dehydrogenative cross-coupling;    electrochemistry;   

DOI  :  10.3762/bjoc.17.178

来源: DOAJ

【 摘 要 】

Electrocatalytic dehydrogenative C(sp3)–H/C(sp)–H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction is easily scalable and requires low concentration of supporting electrolyte and no external chemical oxidants or ligands, providing straightforward and sustainable access to 2-functionalized tetrahydroisoquinolines.

【 授权许可】

Unknown