The Functions, Methods, and Mobility of Mitochondrial Transfer Between Cells

Frontiers in Oncology

卷:11

Yiming Qin¹  Xin Jiang¹  Jiaqi Zhao¹  Qi Yang¹  Yanhong Zhou¹  Qiong Zhou² 

[1] Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, China;

[2] Department of Neurology, Yiyang Central Hospital, Yiyang City, China;

[3] NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;

关键词: mitochondria;    transcellular transport;    tunneling nanotubes;    extracellular vesicles;    Cx43 gap junction;    Miro;   

DOI  :  10.3389/fonc.2021.672781

来源: DOAJ

【 摘 要 】

Mitochondria are vital organelles in cells, regulating energy metabolism and apoptosis. Mitochondrial transcellular transfer plays a crucial role during physiological and pathological conditions, such as rescuing recipient cells from bioenergetic deficit and tumorigenesis. Studies have shown several structures that conduct transcellular transfer of mitochondria, including tunneling nanotubes (TNTs), extracellular vesicles (EVs), and Cx43 gap junctions (GJs). The intra- and intercellular transfer of mitochondria is driven by a transport complex. Mitochondrial Rho small GTPase (MIRO) may be the adaptor that connects the transport complex with mitochondria, and myosin XIX is the motor protein of the transport complex, which participates in the transcellular transport of mitochondria through TNTs. In this review, the roles of TNTs, EVs, GJs, and related transport complexes in mitochondrial transcellular transfer are discussed in detail, as well as the formation mechanisms of TNTs and EVs. This review provides the basis for the development of potential clinical therapies targeting the structures of mitochondrial transcellular transfer.

【 授权许可】

Unknown