Targeting TF-AKT/ERK-EGFR Pathway Suppresses the Growth of Hepatocellular Carcinoma

Frontiers in Oncology

卷:9

Qi Zhou¹  Hui-Lin Jin²  Zi-Jian Zhang³  Huan-Yu Wang⁴  Wen-Ji Zhang⁵  Zi-Hao Xing⁵  Yang Yang⁵  Meng-Ling Yuan⁵  Kun Wang⁵  Qi-Wei Jiang⁵  Jia-Rong Huang⁵  Meng-Ning Wei⁵  Yao Li⁵  Shan-Zhou Huang⁶  Zhi Shi⁶  Xiao-Shun He⁶ 

[1] Department of General Surgery, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, China;

[2] Department of Hepatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;

[3] Department of Hepatobiliary Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China;

[4] Department of Thyroid and Breast Surgery, Nanshan District People's Hospital, Shenzhen, China;

[5] Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China;

[6] Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;

关键词: hepatocellular carcinoma;    tissue factor;    epidermal growth factor receptor;    AKT/ERK;    tumor growth;   

DOI  :  10.3389/fonc.2019.00150

来源: DOAJ

【 摘 要 】

Tissue factor (TF) is a transmembrane glycoprotein to initiate blood coagulation and frequently overexpressed in a variety of tumors. Our previous study has showed that the expression of TF is upregulated and correlated with prognosis in hepatocellular carcinoma (HCC). However, the role and molecular mechanism of TF in the growth of HCC are still unclear. In vitro and in vivo functional experiments were performed to determine the effect of TF on the growth of HCC cells. A panel of biochemical assays was used to elucidate the underlying mechanisms. TF could promote the growth of HCC in vitro and in vivo by activating both ERK and AKT signaling pathways. TF induced EGFR upregualtion, and inhibition of EGFR suppressed TF-mediated HCC growth. In addition, TF protein expression was correlated with EGFR in HCC tissues. TF promotes HCC growth by upregulation of EGFR, and TF as well as EGFR may be potential therapeutic targets of HCC.

【 授权许可】

Unknown