Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases

Cells

卷:8

Na Xie¹  Yi Chen¹  Min Wu²  Pengju Zhang³  Kui Wang⁴  Ping Lin⁴ 

[1] Forensic Medicine, and State Key Laboratory of Biotherapy, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China;

[2] Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203, USA;

[3] Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China;

[4] West China School of Basic Medical Sciences &

关键词: Autophagy;    inflammation;    acute lung injury;    idiopathic pulmonary fibrosis;    COPD;    tuberculosis;    PAH;    cystic fibrosis;   

DOI  :  10.3390/cells8020123

来源: DOAJ

【 摘 要 】

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of cellular components, including protein aggregates, damaged organelles (such as mitochondria, endoplasmic reticulum, and others), as well as various pathogens. Thus, the autophagy pathway represents a major adaptive response for the maintenance of cellular and tissue homeostasis in response to numerous cellular stressors. A growing body of evidence suggests that autophagy is closely associated with diverse human diseases. Specifically, acute lung injury (ALI) and inflammatory responses caused by bacterial infection or xenobiotic inhalation (e.g., chlorine and cigarette smoke) have been reported to involve a spectrum of alterations in autophagy phenotypes. The role of autophagy in pulmonary infection and inflammatory diseases could be protective or harmful dependent on the conditions. In this review, we describe recent advances regarding the protective features of autophagy in pulmonary diseases, with a focus on ALI, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), tuberculosis, pulmonary arterial hypertension (PAH) and cystic fibrosis.

【 授权许可】

Unknown