Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice

International Journal of Clinical and Experimental Medicine

Zhi Liu¹  Li-Ping Shan¹  Wei Liu¹  Xue-Song Dong¹ 

关键词: Paraquat;    poisoning;    acute lung injury;    Toll-like receptor 4;    inflammation;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: To investigate the possible relationship and mechanism of Toll-like receptor 4 (TLR4) and acute lung injury induced by paraquat (PQ) poisoning. Methods: Male wild type mice and male TLR4-knockout mice were used in this study. After paraquat treatment for 24 hours, mice were euthanized and pathology, TLR4 expression and pro-inflammatory cytokines were evaluated. Results: Wild type mice showed deteriorated lung injury, pathological damages and increased TLR4 expression and pulmonary TNF-α, IL-1β and NF-κB p65 levels after PQ treatment. TLR4-deficient mice were significantly resistant to paraquat-induced lung injury. Conclusion: TLR4 may be required as a mediator and may play an important role in acute lung injury induced by paraquat.

【 授权许可】

Unknown