European Journal of Medical Research | 卷:16 |
Study of T Cell subsets and IL-7 protein expression in HIV-1-infected patients after 7 years HAART | |
关键词: HIV-1; highly active antiretroviral therapy (HAART); T cell subsets; IL-7; | |
DOI : 10.1186/2047-783X-16-11-473 | |
来源: DOAJ |
【 摘 要 】
Abstract
Objective
To study the changes in T cell subsets and IL-7 in HIV-1-infected patients after seven years of highly active antiretroviral therapy (HAART).
Methods
Seventy-five individuals were included in this study (25 with effective HAART, 18 with ineffective HAART, 17 untreated HIV+ patients, and 15 volunteers in the HIV negative control group). The counts of CD4+, CD8+, CD8/CD38+, and CD8/HLADR+ T cells as well as the IL-7 protein expression was measured at 5 time points during a period of seven years in patients starting HAART (baseline) and in the HIV negative control group. The expression of CD127 on CD3+ T cells was measured by flow cytometry at a single time point (after 7 years) in patients with HAART and was compared with untreated HIV+ patients and the HIV negative control group.
Results
At baseline CD4+ T cell counts of HIV-1-infected patients were lower than that in the control group (p < 0.01), whereas the CD8+, CD8/HLADR+ and CD8/CD38+ T cell counts were higher than those in the control group (
Conclusion
【 授权许可】
Unknown