Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water

Polymers

卷:12

Yuuki Kawata¹  ThiLien Nguyen¹  Shin-ichi Yusa¹  Kazuhiko Ishihara² 

[1] Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan;

[2] Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan;

关键词: statistical copolymer;    2-methoxyethyl acrylate;    2-methacryloyloxyethyl phosphorylcholine;    self-association behavior;   

DOI  :  10.3390/polym12081808

来源: DOAJ

【 摘 要 】

Biocompatible amphiphilic statistical copolymers P(MEA/MPC_m) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC (m = 6, 12 and 46 mol%). The monomer reactivity ratios of MEA (r_MEA) and MPC (r_MPC) were 0.53 and 2.21, respectively. The r_MEA × r_MPC value of 1.17 demonstrated that statistical copolymerization was successful. P(MEA/MPC₁₂) and P(MEA/MPC₄₆) copolymers did not undergo aggregation in water, whereas the P(MEA/MPC₆) copolymer formed micelles in water with a hydrodynamic radius (R_h) of 96.9 nm and a critical aggregation concentration, which was determined using pyrene fluorescence, at 0.0082 g/L. The restricted motion of the protons in the hydrophobic MEA units in the micelles’ cores provided additional evidence of self-association in P(MEA/MPC₆).

【 授权许可】

Unknown