Matrine: A Promising Natural Product With Various Pharmacological Activities

Frontiers in Pharmacology

卷:11

Quanjun Yang¹  Xipeng Sun¹  Lili Wan¹  Cheng Guo²  Hong Zhang²  Linlin Chen² 

[1] Department of Pharmacy, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China;

[2] School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

关键词: matrine;    cancer;    inflammation;    apoptosis;    autophagy;    cell cycle;   

DOI  :  10.3389/fphar.2020.00588

来源: DOAJ

【 摘 要 】

Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. At present, a large number of studies have proved that matrine has an anticancer effect can inhibit cancer cell proliferation, arrest cell cycle, induce apoptosis, and inhibit cancer cell metastasis. It also has the effect of reversing anticancer drug resistance and reducing the toxicity of anticancer drugs. In addition, studies have reported that matrine has a therapeutic effect on Alzheimer's syndrome, encephalomyelitis, asthma, myocardial ischemia, rheumatoid arthritis, osteoporosis, and the like, and its mechanism is mainly related to the inhibition of inflammatory response and apoptosis. Its treatable disease spectrum spans multiple systems such as the nervous system, circulatory system, and immune system. The antidisease effect and mechanism of matrine are diverse, so it has high research value. This review summarizes recent studies on the pharmacological mechanism of matrine, with a view to providing reference for subsequent research.

【 授权许可】

Unknown