Apoptosis drives cancer cells proliferate and metastasize

Journal of Cellular and Molecular Medicine

Rui-An Wang¹  Qin-Long Li³  Zeng-Shan Li³  Ping-Ju Zheng⁵  Hui-Zhong Zhang⁴  Xiao-Feng Huang³  Su-Min Chi²  An-Gang Yang⁶ 

[1] Department of Pathology of Xijing Hospital, The Fourth Military Medical University, Xi'an, China;Department of Physiology, The Fourth Military Medical University, Xi'an, China;State Key Lab of Tumor Biology, The Fourth Military Medical University, Xi'an, China;Department of Laboratory Medicine of Tangdu Hospital, The Fourth Military Medical University, Xi'an, China;Department of Medical Oncology, Chang'an Hospital, Xi'an, China;Department of Immunology, The Fourth Military Medical University, Xi'an, China

关键词: cancer;    apoptosis;    cell cycle;    metastasis;    inflammation;    stroma;   

DOI  :  10.1111/j.1582-4934.2012.01663.x

来源: Wiley

【 摘 要 】

Abstract

Cancer has been considered to be the result of accumulated gene mutations, which result in uncontrolled cell proliferations for a long time. Cancers are also regarded to be capable of immune evasion. Furthermore, resistance to apoptosis was recognized as an important trait of cancer in the last score of years. However, there are numerous paradoxical issues in this whole set of theory. For example, there is no known set of genes of which mutations are responsible for human cancers. As for the trait of ‘resistance to apoptosis’, the fact is that cancer has increased frequency of apoptosis. The more malignant the tumour is, the more apoptosis shows. In this study, we propose a new theory that apoptosis plays a key role in the malignant progression and metastasis of cancer. The growth of tumour is the difference between tumour cell proliferation and attrition plus the hyperplastic growth of stroma. Increased and unpreventable death caused by innate or environmental factors such as ischaemia and inflammation drives the tumour cells to proliferate relentlessly, move to new lands to establish colonies. In short, increased cell death is the origin of malignancy.

【 授权许可】

CC BY   
© 2012 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

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