Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules

卷:18

关键词: uridine;    glycosyltransferase inhibitors;    antifungal activity;   

DOI  :  10.3390/molecules18078018

来源: DOAJ

【 摘 要 】

New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.

【 授权许可】

Unknown