Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules

Jadwiga Paszkowska¹  Katarzyna Kral¹  Tadeusz Bieg¹  Urszula Nawrot²  Wiesᐪw Szeja¹ 

[1] Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland; E-Mails:;Department of Microbiology, Wroclaw Medical University, T. Chałubińskiego 4, 50-368 Wrocław, Poland; E-Mail:

关键词: uridine;    glycosyltransferase inhibitors;    antifungal activity;   

DOI  :  10.3390/molecules18078018

来源: mdpi

【 摘 要 】

New derivatives of uridine which contain a β-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.