History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA

Substance Abuse Treatment, Prevention, and Policy

卷:12

Sonia Jain¹  Shelly Sun¹  Devesh Vashishtha²  Dan Werb²  Steffanie A. Strathdee²  Richard Garfein²  Maria Luisa Mittal²  Jazmine Cuevas-Mota² 

[1] Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego;

[2] Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego;

关键词: Opioid substitution therapy;    HIV prevention;    HCV prevention;    People who inject drugs;    Methadone;    Opioid agonist treatment;   

DOI  :  10.1186/s13011-017-0126-1

来源: DOAJ

【 摘 要 】

Abstract Background Medication-assisted treatment (MAT) remains the gold standard for the treatment of opioid use disorder. MAT also reduces the frequency of injecting among people who inject drugs (PWID). Relatedly, data suggest that PWID play a key role in the initiation of others into drug injecting by exposing injecting practices to injection-naïve drug users. Our primary objective was to test whether a history of MAT enrollment is associated with a reduced odds of PWID providing injection initiation assistance. Methods Preventing Injecting by Modifying Existing Responses (PRIMER; NIDA DP2-DA040256–01), is a multi-site cohort study assessing the impact of socio-structural factors on the risk that PWID provide injection initiation assistance. Data were drawn from a participating cohort of PWID in San Diego, CA. The primary outcome was reporting ever providing injection initiation assistance; the primary predictor was reporting ever being enrolled in MAT. Logistic regression was used to model associations between MAT enrollment and ever initiating others into injecting while adjusting for potential confounders. Results Participants (n = 354) were predominantly male (n = 249, 70%). Thirty-eight percent (n = 135) of participants reported ever initiating others into injection drug use. In multivariate analysis, participants who reported a history of MAT enrollment had significantly decreased odds of ever providing injection initiation assistance (Adjusted Odds Ratio [AOR]: 0.62, 95% Confidence Interval [CI]: 0.39–0.99). Conclusions These preliminary findings suggest an association between MAT enrollment and a lower odds that male PWID report providing injection initiation assistance to injection-naïve drug users. Further research is needed to identify the pathways by which MAT enrollment may impact the risk that PWID initiate others into drug injecting.

【 授权许可】

Unknown