Chronic obstructive pulmonary disease severity in middle-aged and older men with osteoporosis associates with decreased bone formation

Osteoporosis and Sarcopenia

卷:6

Toshiharu Mori¹  Hokuto Fukuda²  Ke-Yong Wang²  Ken Sabanai²  Yoshiaki Yamanaka²  Yasuaki Okada²  Manabu Tsukamoto²  Eiichiro Nakamura³  Akinori Sakai⁴  Kazuhiro Yatera⁵  Satoshi Kuboi⁶  Takeshi Hanagiri⁷ 

[1] Corresponding author. Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.;

[2] Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;

[3] Department of Orthopedic Surgery, Shin-Kokura Hospital, Federation of National Public Service, Kitakyushu, Japan;

[4] Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;

[5] Department of Respiratory Medicine, Shin-Kokura Hospital, Federation of National Public Service, Kitakyushu, Japan;

[6] Department of Thoracic Surgery, Shin-Kokura Hospital, Federation of National Public Service, Kitakyushu, Japan;

[7] Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;

关键词: Chronic obstructive pulmonary disease;    Alkaline phosphatase;    Procollagen type 1 N-Terminal propeptide;    Male osteoporosis;    Tartrate-resistant acid phosphatase 5b;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: Chronic obstructive pulmonary disease (COPD) is a risk factor for osteoporosis. Nevertheless, much remains unclear regarding the bone metabolism dynamics associated with COPD. The present study focuses on the associations between the COPD severity and serum bone metabolism biomarkers. Methods: We enrolled 40 patients who visited the orthopedics departments at our institutions and underwent dual-energy X-ray absorptiometry between September 2015 and December 2017. Only male osteoporosis patients over 45 years of age were included, and 5 patients were excluded due to disease or use of internal medicines affecting bone metabolism. All subjects underwent lung function testing, spine radiography, and blood tests. We measured percent forced expiratory volume in 1 second (%FEV1), which reflects COPD severity, and we examined the relationships between %FEV1 and serum levels of bone metabolism biomarkers. Results: All subjects were diagnosed with osteoporosis based on T-scores. %FEV1 correlated with body weight, body mass index (BMI), and Z-score/T-scores. %FEV1 moderately correlated with serum levels of alkaline phosphatase (ALP), procollagen type 1 N-terminal propeptide (P1NP), and tartrate-resistant acid phosphatase 5b in the partial correlation analysis adjusted for BMI or T-score in the lumbar vertebrae. We performed a hierarchical multiple regression analysis to identify that serum ALP and P1NP were the independent explanatory variables to %FEV1 independent of other factors. Conclusions: The data suggest that the COPD severity in middle-aged and older men with osteoporosis associates with decreased bone formation. COPD patients may exhibit bone metabolism dynamics characterized by low bone turnover with osteogenesis dysfunction as COPD becomes severe.

【 授权许可】

Unknown