Combination antibiotic therapy for treatment of a patient with infected prosthesis and peri-prosthetic abscess due to Klebsiella pneumoniae harboring New Delhi Metallo (NDM) beta-lactamase

IDCases

卷:27

Elan Goldwyn¹  Sorana Segal-Maurer¹  Janice Burns²  Noriel Mariano³  George D. Rodriguez⁴  Nishant Prasad⁴  Monica Cespedes Santana⁵  Carl Urban⁵  Ting Ting Wong⁵ 

[1] Control, Quality Management, NewYork-Presbyterian Queens, Flushing, NY 11355, USA;

[2] Correspondence to: The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, N-011, Flushing, NY 11355, USA.;

[3] Weill Cornell Medicine, Cornell University, New York, NY 10065, USA;

[4] Infection Prevention &

[5] The Dr. James J. Rahal, Jr. Division of Infectious Diseases, Department of Medicine, NewYork-Presbyterian Queens, Flushing, NY 11355, USA;

关键词: New Delhi metallo-beta-lactamase;    Multi-drug resistance;    Combination therapy;    Infection control;   

DOI  :  

来源: DOAJ

【 摘 要 】

Treatment options for patients infected with multi-drug resistant gram-negative bacteria harboring metallo-beta-lactamases (MBLs) requires precision therapy. We present the case of a 20 year-old male with a right distal femoral peri-prosthetic abscess with presumed infected hardware and osteomyelitis in whom four multi-drug resistant gram negative bacteria were isolated. The rapid identification of an MBL producing organism, novel combination of therapy, and prompt infection prevention enforcement and education led to appropriate treatment of our patient as well as prevention of spread of organisms during and after hospitalization. This case illustrated successful management of multiple challenges faced by patients infected and/or harboring extensively resistant bacteria.

【 授权许可】

Unknown