Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients

Frontiers in Endocrinology

卷:12

Xunan Wu¹  Panpan Zhang¹  Ling Yang¹  Chenxi Wang¹  Xia Deng¹  Haoxiang Li¹  Zhicong Zhao¹  Guoyue Yuan¹  Ke Chen¹  Li Zhao¹  Zhensheng Cai¹  Yanyan Li² 

[1] Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China;

[2] Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, China;

关键词: ectodysplasin A;    T2DM;    insulin resistance;    hepatokine;    hyperlipidemia;   

DOI  :  10.3389/fendo.2021.737624

来源: DOAJ

【 摘 要 】

ObjectiveEctodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diagnosed type 2 diabetes mellitus (T2DM) patients, and to explore the relationships between serum EDA levels and various metabolic indexes.MethodsA total of 184 subjects were enrolled in the study, including 92 subjects with newly diagnosed T2DM and 92 subjects with age- and sex-matched normal glucose tolerance (NGT). Serum EDA levels were determined using enzyme-linked immunosorbent assay (ELISA). Oral glucose tolerance test, glycosylated hemoglobin c (HbA1c), and insulin were also measured.ResultsSerum EDA levels were significantly increased in the T2DM group than in the NGT group (359.91 ± 117.99 vs. 265.82 ± 86.51 pg/ml, p < 0.001). Serum EDA levels were positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), HbA1c, 2-hour postprandial plasma glucose (2hPG), fasting plasma insulin (FIns), fasting C peptide (FCP), triglyceride (TG), HOMA-IR, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) and HOMA-β (p < 0.05). Multiple stepwise regression analysis demonstrated that 2hPG and FIns were independent influencing factors of serum EDA level (p < 0.05). Logistic regression analysis showed that serum EDA level was significantly independently correlated with T2DM (p < 0.05).ConclusionsSerum EDA levels are significantly higher in T2DM patients, suggesting that EDA may play a role in the occurrence and development of T2DM.

【 授权许可】

Unknown