Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario

Journal of Clinical Medicine

卷:10

Jacopo Demurtas¹  Stefano Busani²  Alessandro Andreani³  GaiaFrancesca Cappiello³  AnnaValeria Samarelli³  Dario Andrisani³  Filippo Gozzi³  Riccardo Fantini³  Luca Tabbì³  Alessandro Marchioni³  Ivana Castaniere³  Giulia Bruzzi³  Linda Manicardi³  Enrico Clini³  Roberto Tonelli³ 

[1] Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41124 Modena, Italy;

[2] Intensive Care Unit, University Hospital of Modena and Reggio Emilia, 41124 Modena, Italy;

[3] University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy;

关键词: SARS-CoV-2;    COVID-19;    mechanical ventilation;    spontaneous breathing;    acute respiratory distress syndrome;    acute respiratory failure;   

DOI  :  10.3390/jcm10050975

来源: DOAJ

【 摘 要 】

The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessive spontaneous breathing may acquire critical importance, being one potential and important driver of lung injury and disease progression. The consequences of this acute lung damage may impair lung structure, forecasting the model of a fragile respiratory system. This perspective article aims to analyze the progression of injured lung phenotypes across the SARS-CoV-2 induced respiratory failure, pointing out the role of spontaneous breathing and also tackling the specific respiratory/ventilatory strategy required by the fragile lung type.

【 授权许可】

Unknown