The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

Nutrients

卷:11

StevenP. Miller¹  JaneE. Harding²  BarbaraE. Cormack³  FrankH. Bloomfield³ 

[1] Department of Paediatrics, Hospital for Sick Children, Toronto, ON M5G, Canada;

[2] Liggins Institute, University of Auckland, Auckland 1142, New Zealand;

[3] Starship Child Health, Auckland City Hospital, Auckland 1023, New Zealand;

关键词: nutrition;    parenteral nutrition;    amino acid;    extremely low birthweight;    preterm;    newborn;    gestational age;    growth;    infant;    premature;    nutrition disorders/etiology;    follow up;    brain;   

DOI  :  10.3390/nu11092029

来源: DOAJ

【 摘 要 】

Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, and in particular, protein intake, affects neurodevelopment in extremely preterm babies. Observational studies consistently report that higher intravenous and enteral protein intakes are associated with improved growth and possibly neurodevelopment, but differences in methodologies and combinations of intravenous and enteral nutrition strategies make it difficult to determine the effects of each intervention. Unfortunately, there are few randomized controlled trials of nutrition in this population conducted to determine neurodevelopmental outcomes. Substantial variation in reporting of trials, both of nutritional intakes and of outcomes, limits conclusions from meta-analyses. Future studies to determine the effects of nutritional intakes in extremely preterm babies need to be adequately powered to assess neurodevelopmental outcomes separately in boys and girls, and designed to address the many potential confounders which may have clouded research findings to date. The development of minimal reporting sets and core outcome sets for nutrition research will aid future meta-analyses.

【 授权许可】

Unknown