A comprehensive review on biocompatible Mg-based alloys as temporary orthopaedic implants: Current status, challenges, and future prospects

Journal of Magnesium and Alloys

卷:10

Sumantra Mandal¹  Darothi Bairagi¹ 

[1] Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Kharagpur 721302, India;

关键词: Mg-based alloys;    Biomaterials;    Temporary implants;    Biocompatibility;    Degradation behaviour;    orthopaedic fixtures;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mg and its alloys are drawing huge attention since the last two decades as a viable option for temporary implants applications. A commendable progress has already been made in the development of these alloys. The biodegradable nature of Mg, appreciable biocompatibility of elemental Mg, and its close resemblance to natural bone in terms of density and elastic modulus make them highly preferable option amongst other available alternatives in this field. This review article presents an overview covering the recent advancements made in the field of Mg-based biodegradable implants for orthopaedic implant applications. The paper focuses on alloy development and fabrication techniques, the state of the art of important Mg-based alloy systems in terms of their mechanical properties, in-vitro and in-vivo degradation behaviour and cytotoxicity. Further, the paper reviews the current progress achieved in the clinical transition of Mg-based alloys for orthopaedic fixtures. The review also includes the degradation mechanisms of the alloys in physiological environment and highlights the mismatch existing between the rate of bone healing and alloy degradation due to rapid corrosion of the alloys in such environment, which has still restricted their widespread application. Finally, the surface coating techniques available for the alloys as an effective way to reduce the degradation rate are reviewed, followed by a discussion on the future research prospects.

【 授权许可】

Unknown