Biocompatibility of a micro-arc oxidized ZrCuAlAg bulk metallic glass

Journal of Materials Research and Technology

Yu Sun¹  Hongbo Fan²  Yongjiang Huang²  Zhiliang Ning³  Jianfei Sun³  Fuyang Cao⁴  Xiang Cheng⁴  Lunyong Zhang⁴ 

[1] Corresponding author.;National Key Laboratory for Precision Hot Processing of Metals, Harbin Institute of Technology, Harbin, 150001, China;Anhui Xinli Consulting Co., Ltd of Electric Power Technology, Hefei, 230601, China;School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China;

关键词: Biomaterials;    Bulk metallic glasses;    Zr based BMGs;    Biocompatibility;   

DOI  :  

来源: DOAJ

【 摘 要 】

Developing materials with high biocompatibility is key to improve the artificial medical implant. Bulk metallic glasses (BMGs) based on Zr have been proposed as promising biomaterials. The present work investigated the biocompatibility of Zr46(Cu4.5/5.5Ag1/5.5)46Al8 BMG in depth by using several biomedical methods. Our results indicate that the BMG material treated by micro-arc oxidation technology (MAO) has good biocompatibility comparable to as-cast Ti–6Al–4V alloy. MAO introduced high density of pores and hydroxyapatite in the surface layer. At a moderate MAO voltage, 350 V, a surface with the highest density of uniform size pores and suitable surface roughness was obtained. The BMG material treated at 350 V thus demonstrated the strongest platelet adhesion, the best blood compatibility, the weakest oral mucous membrane irritation, the weakest inflammation, and fastest recovery of injured cells during the subcutaneous implantation tests, in comparison with the samples treated at other voltages. These results may advance the applications of Zr-based BMGs as biomaterials in future.

【 授权许可】

Unknown