Deubiquitinases: Modulators of Different Types of Regulated Cell Death

International Journal of Molecular Sciences

卷:22

Gyuho Hwang¹  Jaewhan Song¹  Seungyeon Kim¹  Choong-Sil Lee² 

[1] Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea;

[2] Integrated OMICS for Biomedical Science, World Class University, Yonsei University, Seoul 120-749, Korea;

关键词: deubiquitinase;    apoptosis;    necroptosis;    pyroptosis;    ferroptosis;    paraptosis;   

DOI  :  10.3390/ijms22094352

来源: DOAJ

【 摘 要 】

The mechanisms and physiological implications of regulated cell death (RCD) have been extensively studied. Among the regulatory mechanisms of RCD, ubiquitination and deubiquitination enable post-translational regulation of signaling by modulating substrate degradation and signal transduction. Deubiquitinases (DUBs) are involved in diverse molecular pathways of RCD. Some DUBs modulate multiple modalities of RCD by regulating various substrates and are powerful regulators of cell fate. However, the therapeutic targeting of DUB is limited, as the physiological consequences of modulating DUBs cannot be predicted. In this review, the mechanisms of DUBs that regulate multiple types of RCD are summarized. This comprehensive summary aims to improve our understanding of the complex DUB/RCD regulatory axis comprising various molecular mechanisms for diverse physiological processes. Additionally, this review will enable the understanding of the advantages of therapeutic targeting of DUBs and developing strategies to overcome the side effects associated with the therapeutic applications of DUB modulators.

【 授权许可】

Unknown