Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia

Viruses

卷:13

Ahmad Bakur Mahmoud¹  Rajaa M. Al-Raddadi²  Abdullah Algaissi³  Adel M. Abuzenadah⁴  Almohanad A. Alkayyal⁵  Rahaf Alhabbab⁶  Abdulelah A. Alfaraj⁷  Omaima I. Shabouni⁸  Ahdab Alsaieedi⁹  Rwaa H. Abdulal⁹  Sara Almahboub⁹  Rowa Y. Alhabbab⁹  Mohamed A. Alfaleh⁹  Najwa D. Aljehani⁹  Anwar M. Hashem⁹  Sawsan S. Alamri⁹  Turki S. Abujamel⁹ 

[1] College of Applied Medical Sciences, Taibah University, Almadinah Almunwarah 42353, Saudi Arabia;

[2] Department of Community Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

[3] Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia;

[4] Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

[5] Department of Medical Laboratory Technology, University of Tabuk, Tabuk 71491, Saudi Arabia;

[6] Department of Oral and Maxillofacial Surgery, King Fahad General Hospital, Jeddah 23325, Saudi Arabia;

[7] Department of Phlebotomy, Blood Bank & Laboratory, King Fahad General Hospital, Jeddah 23325, Saudi Arabia;

[8] Ministry of Health, Jeddah 23325, Saudi Arabia;

[9] Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

关键词: SARS-CoV-2;    COVID-19 pandemic;    anti-S Abs;    seroprevalence;    Jeddah;    HCWs;   

DOI  :  10.3390/v13071413

来源: DOAJ

【 摘 要 】

Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy.

【 授权许可】

Unknown