The Role of Configurational Entropy in Amorphous Systems

Pharmaceutics

卷:2

关键词: configurational entropy;    amorphous;    molecular mobility;    solubility;   

DOI  :  10.3390/pharmaceutics2020224

来源: DOAJ

【 摘 要 】

Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.

【 授权许可】

Unknown