The Role of Configurational Entropy in Amorphous Systems

Pharmaceutics

Kirsten A. Graeser¹  James E. Patterson²  J. Axel Zeitler³ 

[1] School of Pharmacy, University of Otago, Dunedin, New Zealand;Pharmaceutical Development, GlaxoSmithKline, Harlow, CM19 5AW, UK;Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK

关键词: configurational entropy;    amorphous;    molecular mobility;    solubility;   

DOI  :  10.3390/pharmaceutics2020224

来源: mdpi

【 摘 要 】

Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.