Comparison of Ti-Based Coatings on Silicon Nanowires for Phosphopeptide Enrichment and Their Laser Assisted Desorption/Ionization Mass Spectrometry Detection

Nanomaterials

卷:7

Ahmed Addad¹  Rabah Boukherroub²  Yannick Coffinier²  Abderrahmane Hamdi²  Ievgen Kurylo² 

[1] Unité Matériaux et Transformations (UMET), UMR CNRS 8207, Université Lille1, Cité Scientifique, 59655 Villeneuve d’Ascq, France;

[2] University Lille, CNRS, Centrale Lille, ISEN, University Valenciennes, IEMN, UMR CNRS 8520, Avenue Poincaré, BP 60069, 59652 Villeneuve d’Ascq, France;

关键词: silicon nanowires;    titania;    phosphopeptides;    LDI-MS;    serum;   

DOI  :  10.3390/nano7090272

来源: DOAJ

【 摘 要 】

We created different TiO2-based coatings on silicon nanowires (SiNWs) by using either thermal metallization or atomic layer deposition (ALD). The fabricated surfaces were characterized by X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDX), and reflectivity measurements. Surfaces with different TiO2 based coating thicknesses were then used for phosphopeptide enrichment and subsequent detection by laser desorption/ionization mass spectrometry (LDI-MS). Results showed that the best enrichment and LDI-MS detection were obtained using the silicon nanowires covered with 10 nm of oxidized Ti deposited by means of thermal evaporation. This sample was also able to perform phosphopeptide enrichment and MS detection from serum.

【 授权许可】

Unknown