SAFETY AND OUTCOME OF INTRAVENOUS THROMBOLYSIS WITH rtPA IN PATIENTS WITH ATRIAL FIBRILLATION

Romanian Journal of Neurology

卷:11

Cristina Tiu¹  Elena Terecoasa¹  Maria Alonso de Lecinana²  Jaime Masjuan²  Marta Guillan²  Victor Sanchez-Gonzalez² 

[1] Stroke Unit, Department of Neurology, Emergency University Hospital, Bucharest;

[2] Stroke Unit, Department of Neurology, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid;

关键词: thrombolysis;    rtpa;    atrial fi brillation;    cardioembolic stroke;    outcome;    safety;   

DOI  :  10.37897/RJN.2012.3.3

来源: DOAJ

【 摘 要 】

Background and purpose. Intravenous administration of recombinant tissue plasminogen activator (rtPA) is approved for the treatment of patients with acute ischemic stroke. It is still controversial if in patients with ischemic stroke due to atrial fibrillation this treatment has the same efficacy as in patients with ischemic stroke due to other etiologies. The present study aimed to compare the safety and outcome of intravenous thrombolysis with rtPA between patients with stroke due to atrial fibrillation, due to other cardiac sources of emboli and due to large-vessel disease.Methods. Retrospective analysis of 463 patients treated with rtPA in the Stroke Unit of Ramon y Cajal University Hospital, Madrid, between January 2004 and December 2011. Patients were divided in three subgroups according to stroke etiology: cardioembolic stroke due to atrial fibrillation, cardioembolic stroke due to a cardiac disease other than atrial fibrillation, stroke due to large-vessel disease. The outcome measures of the study were: symptomatic intracranial hemorrhage transformation, modified Rankin score and mortality at three months.Results. The results of the multivariate analysis showed that stroke etiology has no influence on functional outcome (p = 0.181), symptomatic intracranial hemorrhage (p = 0.093) and mortality at three months (p = 0.091). Age and baseline NIHSS scores are independent predictors for both functional outcome and mortality.Conclusion. Stroke outcome after intravenous thrombolysis with rtPA is not influenced by the stroke etiology.

【 授权许可】

Unknown