Platelet Aggregation Inhibitors and Anticoagulants Delay Surgery for Hip Fractures

Applied Sciences

卷:10

Cristina Tudoran¹  Teodora Hoinoiu²  Bogdan Deleanu³  Andrei Ghiorghitoiu³  Horia Haragus³  Adrian Todor⁴  Nevena Velimirovici⁵  Oana Suciu⁵  RoxanaRamona Onofrei⁵ 

[1] 2nd Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania;

[2] Department of Clinical Practical Skils, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania;

[3] Department of Orthopedics and Trauma, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania;

[4] Department of Orthopedics, Traumatology and Pediatric Orthopedics, “Iuliu Hatieganu” University of Medicine and Pharmacy, No 8 Victor Babes Str, 400000 Cluj-Napoca, Romania;

[5] Department of Rehabilitation, “Victor Babes” University of Medicine and Pharmacy, No 2 Eftimie Murgu Square, 300041 Timisoara, Romania;

关键词: aged;    anesthesia/methods;    anticoagulants;    hip fractures/drug therapy;    hip fractures/surgery;    length of stay;   

DOI  :  10.3390/app10238617

来源: DOAJ

【 摘 要 】

Background: we aimed to analyze the influence of antithrombotic medication in delaying surgery for fragility hip fractures; Method: a total of 312 consecutive hip fracture cases over 55 years who underwent surgery in our Orthopedic Clinic; Results: of these, 90 patients received chronic antithrombotic medication. There were no differences between the medicated group and controls (n = 222) regarding age, gender, type of fracture and haemoglobin at admittance. However, median time to surgery was significantly longer in the medicated group: 4(3–6) days compared to 2(1–4) (p < 0.0001). By type of medication, time to surgery was: 3(1–4) days for acetylsalicylic acid (n = 44), 6(5.25–7.75) days for clopidogrel (n = 15), 4.5(4–7) days for acenocoumarin (n = 18) and 5(4–7.25) days for novel direct oral anticoagulants (n = 13). The Charlson comorbidity index was significantly higher in the medicated group: 5 [4–5] versus 4 [3–5]. There were no differences in transfusions except for fresh frozen plasma, which was administered more in the medicated patients; Conclusions: the prevalence of platelet aggregation inhibitors and anticoagulant use among fragility hip fracture patients is high, with almost a third using some form of antithrombotic medication. This may significantly lengthen time to surgery.

【 授权许可】

Unknown