Rats fed linseed oil in microemulsion forms enriches the cardiac sarcoplasmic reticulum lipids with docosahexaenoic acid and lower calcium transport

Journal of Functional Foods

卷:5

B.R. Lokesh¹  D. Sugasini² 

[1] Corresponding author. Tel.: [phone];

[2] Department of Lipid Science and Traditional Foods, CSIR-Central Food Technological Research Institute, Mysore 570 020, India;

关键词: Alpha linolenic acid;    Docosahexaenoic acid;    Microemulsions;    Sarcoplasmic reticulum;    Ca2+Mg2+ ATPase;    Ca2+ transport;   

DOI  :  

来源: DOAJ

【 摘 要 】

The effect of feeding rats with whey protein or lipoid microemulsion of n-3 rich linseed oil (LSO), and n-6 rich sunflower oil (SNO) compared to native or microemulsion forms of each oil for 60 days on fatty acid composition, Ca2+Mg2+ ATPase, Ca2+ uptake and membrane fluidity of rat cardiac sarcoplasmic reticulum (SR) were assessed. Rats consuming LSO in lipoid microemulsion showed higher levels of ALA (18:3, n-3) conversion to DHA (22:6, n-3) when compared to rats given LSO in native form. Compared to all other dietary treatments, the alterations in the n-6/n-3 PUFA composition of SR of rats given LSO in lipoid microemulsion effected the greatest changes in Ca2+Mg2+ ATPase activity and Ca2+ uptake which effectively reduced Ca2+ transport. Therefore, the LSO in lipoid microemulsion confers similar heart healthy fatty acid compositional and calcium transport changes and potentially anti-arrhythmic effects similar to fish oils.

【 授权许可】

Unknown