Ionic Liquid-in-Oil Microemulsions as Potential Carriers for the Transdermal Delivery of Methotrexate

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Hiromu Yoshiura¹  Makoto Aso²  Masahiro Goto²  Miki Tamura²  Noriho Kamiya² 

[1] Technical Department, BioKyowa Inc.;Department of Applied Chemistry, Graduate School of Engineering, Kyushu University

关键词: Ionic Liquid;    Microemulsions;    Sparingly Soluble Drugs;    Transdermal Drug Delivery;   

DOI  :  10.1252/jcej.13we009

来源: Maruzen Company Ltd

【 摘 要 】

References(10)Cited-By(1)Ionic liquid-in-oil (IL/o) microemulsion (ME) techniques have been employed to increase the solubility of sparingly soluble drugs and enhance the extent of their topical and transdermal delivery. Methotrexate (MTX) has been used as a model drug in the current study. The size and size distributions of the ME droplets in the presence and in the absence of MTX were determined by dynamic light scattering analysis. The mean droplet diameter of the ME droplets containing 4 mg/mL of MTX was less than 20 nm, and smaller than the corresponding value observed in the absence of MTX. MTX was incorporated into IL droplets as well as other formulations and its permeation across Yucatan micropig (YMP) porcine skin evaluated. The use of IL/o ME has been shown to dramatically increase MTX administration. The results obtained in this study reveal the versatility of IL/o MEs as efficient drug delivery systems for sparingly soluble drugs.

【 授权许可】

Unknown