In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

Diagnostics

卷:5

Henrik Gutte¹  Sofie Rahbek¹  Helle H. Johannesen¹  Andreas Kjaer¹  Liselotte Højgaard¹  Adam E. Hansen¹  Jan Ardenkjaer-Larsen²  Annemarie T. Kristensen³  Majbrit M.E. Larsen³ 

[1] Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark;

[2] Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark;

[3] Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark;

关键词: cancer;    dynamic nuclear polarization;    hyperpolarized;    13C-pyruvate;    MR;    18F-FDG-PET;    PET/MR;    molecular imaging;    hyperPET;   

DOI  :  10.3390/diagnostics5030287

来源: DOAJ

【 摘 要 】

In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that 18F-FDG-PET may not always reflect the Warburg effect in all tumors.

【 授权许可】

Unknown