In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

Diagnostics

Henrik Gutte³  Adam E. Hansen³  Majbrit M.E. Larsen¹  Sofie Rahbek³  Helle H. Johannesen³  Jan Ardenkjaer-Larsen²  Annemarie T. Kristensen¹  Liselotte Højgaard³  Andreas Kjaer³ 

[1] Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark; E-Mails:;Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark; E-Mail:;Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; E-Mails:

关键词: cancer;    dynamic nuclear polarization;    hyperpolarized;    ¹³C-pyruvate;    MR;    ¹⁸F-FDG-PET;    PET/MR;    molecular imaging;    hyperPET;   

DOI  :  10.3390/diagnostics5030287

来源: mdpi

【 摘 要 】

In this communication the mismatch between simultaneous ¹⁸F-FDG-PET and a ¹³C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that ¹⁸F-FDG-PET may not always reflect the Warburg effect in all tumors.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.