The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization

Non-Coding RNA

卷:7

Itziar Gonzalez-Moro¹  Izortze Santin¹  Ainara Castellanos-Rubio²  Maialen Sebastian-delaCruz²  Ane Olazagoitia-Garmendia² 

[1] Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain;

[2] Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, 48940 Leioa, Spain;

关键词: long non-coding RNA;    mRNA stability;    RNA binding protein;    microRNA;    gene expression;   

DOI  :  10.3390/ncrna7010003

来源: DOAJ

【 摘 要 】

mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability.

【 授权许可】

Unknown