Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance

International Journal of Molecular Sciences

Hoin Kang¹  Chongtae Kim¹  Heejin Lee¹  Wook Kim² 

[1] Department of Biochemistry, College of Medicine, Catholic University of Korea, Seoul 137-701, Korea; E-Mails:;Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea

关键词: ribonucleoprotein complex;    RNA binding protein;    microRNAs;    drug resistance;    mRNA stability;    translation;   

DOI  :  10.3390/ijms140817204

来源: mdpi

【 摘 要 】

Acquisition of drug resistance leads to failure of anti-cancer treatments and therapies. Although several successive chemotherapies are available, along with efforts towards clinical applications of new anti-cancer drugs, it is generally realized that there is a long way to go to treat cancers. Resistance to anti-cancer drugs results from various factors, including genetic as well as epigenetic differences in tumors. Determining the molecular and cellular mechanisms responsible for the acquisition of drug resistance may be a helpful approach for the development of new therapeutic strategies to overcome treatment failure. Several studies have shown that the acquisition of drug resistance is tightly regulated by post-transcriptional regulators such as RNA binding proteins (RBPs) and microRNAs (miRNAs), which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, epithelial-mesenchymal transition, and drug metabolism. Here, we review our current understanding of ribonucleoprotein complexes, including RBPs and miRNAs, which play critical roles in the acquisition of drug resistance and have potential clinical implications for cancer.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland