The role of non-coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Cancer Communications

article

Xiang Meng¹  Qiu-Yue Lou²  Wen-Ying Yang¹  Yue-Rong Wang¹  Ran Chen³  Lu Wang¹  Tao Xu⁴  Lei Zhang¹ 

[1] Key Lab. of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology;Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University;School of Stomatology, Anhui Medical University;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province;School of Pharmacy, Anhui Key Lab. of Bioactivity of Natural Products, Anhui Medical University;Department of Periodontology, Anhui Stomatology Hospital affiliated to Anhui Medical University

关键词: drug delivery;    drug resistance;    long non-coding RNAs;    microRNAs;    non-coding RNA (ncRNA);    oral squamous cell carcinoma;   

DOI  :  10.1002/cac2.12194

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5-fluorouracil, and paclitaxel have now become the first-line options for OSCC patients. Nevertheless, most OSCC patients eventually acquire drug resistance, leading to poor prognosis. With the discovery and identification of non-coding RNAs (ncRNAs), the functions of dysregulated ncRNAs in OSCC development and drug resistance are gradually being widely recognized. The mechanisms of drug resistance of OSCC are intricate and involve drug efflux, epithelial-mesenchymal transition, DNA damage repair, and autophagy. At present, strategies to explore the reversal of drug resistance of OSCC need to be urgently developed. Nano-delivery and self-cellular drug delivery platforms are considered as effective strategies to overcome drug resistance due to their tumor targeting, controlled release, and consistent pharmacokinetic profiles. In particular, the combined application of new technologies (including CRISPR systems) opened up new horizons for the treatment of drug resistance of OSCC. Hence, this review explored emerging regulatory functions of ncRNAs in drug resistance of OSCC, elucidated multiple ncRNA-meditated mechanisms of drug resistance of OSCC, and discussed the potential value of drug delivery platforms using nanoparticles and self-cells as carriers in drug resistance of OSCC.

【 授权许可】

CC BY|CC BY-NC-ND