Urinary Mineral Concentrations in European Pre-Adolescent Children and Their Association with Calcaneal Bone Quantitative Ultrasound Measurements

International Journal of Environmental Research and Public Health

卷:13

Yiannis A. Kourides¹  Toomas Veidebaum²  Staffan Marild³  Dénes Molnár⁴  Stefaan De Henauw⁵  Karen Van den Bussche⁵  Isabelle Sioen⁵  Luis A. Moreno⁶  Diana Herrmann⁷  Wolfgang Ahrens⁷  Fabio Lauria⁸ 

[1] Child Health Research and Education Institute, 56 Stavrou Street, Strovolos 2035, Cyprus;

[2] Department of Chronic Diseases, National Institute for Health Development, Hiiu str. 42, Tallinn 11619, Estonia;

[3] Department of Pediatrics, Institute of Clinical Sciences, The Queen Silvia Children’s Hospital, Sahlgrenska Academy at University of Gothenburg, Göteborg 416 85, Sweden;

[4] Department of Pediatrics, University of Pécs, József Attila str. 7, Pécs H-7623, Hungary;

[5] Department of Public Health, Ghent University, 4K3, De Pintelaan 185, Ghent 9000, Belgium;

[6] GENUD (Growth, Exercise, Nutrition and Development) Research Group, Facultad de Ciencias de la Salud, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Universidad de Zaragoza, C/Domingo Miral s/n, Zaragoza 50009, Spain;

[7] Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraβe 30, Bremen D-28359, Germany;

[8] Unit of Epidemiology and Population Genetics, Institute of Food Sciences, Consiglio Nazionale delle Ricerche, Avellino 83100, Italy;

关键词: potassium;    sodium;    calcium;    magnesium;    phosphate;    children;    calcaneal quantitative ultrasound;   

DOI  :  10.3390/ijerph13050471

来源: DOAJ

【 摘 要 】

This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1–11.9 years, 50.6% boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.

【 授权许可】

Unknown