Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression

Molecular Therapy: Nucleic Acids

卷:22

Yujia Guo¹  Yongyan Wu²  Li Dai³  Yan Lu⁴  Huizheng Li⁵  Wei Gao⁶  Xiwang Zheng⁷  Wei Xu⁸  Linshi Zhang⁹  Fengsheng Dai¹⁰  Changming An¹⁰ 

[1] Corresponding author: Yongyan Wu, PhD, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China.;

[2] Department of Otolaryngology Head &

[3] Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, P. R. China;

[4] Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China;

[5] Neck Surgery, The First Hospital of Jinzhou Medical University, Jinzhou 121001, P. R. China;

[6] Peking Union Medical College, Beijing 100021, P. R. China;

[7] Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China;

[8] Department of Head and Neck Surgery, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences &

[9] Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China;

关键词: cancer;    N6-methyladenosine;    non-coding RNA;    microRNA;    long non-coding RNA;    circular RNA;   

DOI  :  

来源: DOAJ

【 摘 要 】

N6-methyladenosine (m6A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m6A regulators can lead to an imbalance in m6A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting m6A regulators. In this review, we describe the functional crosstalk between m6A and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and m6A modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions.

【 授权许可】

Unknown