The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment

International Journal of Environmental Research and Public Health

卷:14

Prayoon Srikumpol¹  Susan Woskie²  Noppanun Nankongnab³  Anu Surach³  Pornpimol Kongtip³  Akkarat Phamonphon³  Benyachalee Techasaensiri⁴  Jane Adams⁵  Aree Thongsuksai⁶  Supha Sangprasert⁷ 

[1] Amnatcharoen Hospital, 291 Arunprasert Road, Muang, Amnatcharoen 37000, Thailand;

[2] College of Health Sciences, University of Massachusetts Lowell, One University Ave, Lowell, MA 01854-2867, USA;

[3] Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvithi Road, Bangkok 10400, Thailand;

[4] Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand;

[5] Department of Psychology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA;

[6] Paholpolpayuhasena Hospital, 572 Sangchuto Road, Ban Tai, Kanchanaburi 71000, Thailand;

[7] Sawanpracharak Hospital, 43 Autakavee Road, Paknumpo, Muang, Nakhon Sawan 60000, Thailand;

关键词: organophosphate metabolites;    pregnant women;    infant neurodevelopment;    Bayley Scales of Infant and Toddler Development;   

DOI  :  10.3390/ijerph14060570

来源: DOAJ

【 摘 要 】

A birth cohort was begun to investigate the levels and sources of pesticide exposure in pregnant women living in Thailand, and to examine the effects of pesticide exposure on infant neurodevelopment at five months of age. Subjects were interviewed using questionnaires regarding their demographic characteristics, educational background, and work and home activities related to pesticide exposures. Spot urine samples were collected at 28 weeks gestation and analyzed by gas chromatography-mass spectrometry to determine maternal metabolite levels of organophosphate pesticides including dimethyl phosphate (DMP); total DEP (diethyl phosphate (DEP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), and total DAP (the sum of all metabolite levels). At five months of age, infant development was evaluated using the Bayley Scales of Infant and Toddler Development-III (Bayley-III). Higher total DEP and total DAP metabolite levels from the mother at 28 weeks’ gestation were significantly associated with reduced motor composite scores on the Bayley-III at five months of age. The total DEP levels were also significantly associated with reduced cognitive composite scores. Prenatal concentrations of maternal urinary metabolites were associated with infant cognitive and motor development. The results of several studies now suggest the need for public health intervention to reduce prenatal pesticide exposures from both agricultural and domestic use.

【 授权许可】

Unknown