New Drugs from Marine Organisms in Alzheimer’s Disease

Marine Drugs

卷:14

Palma Lamonaca¹  Patrizia Russo¹  Aliaksei Kisialiou¹  Rossana Moroni¹  Giulia Prinzi¹  Massimo Fini² 

[1] Clinical and Molecular Epidemiology Division, IRCCS “San RaffaelePisana” Via di Valcannuta, 247, RomeI-00166, Italy;

[2] Scientific Direction, IRCCS “San RaffaelePisana” Via di Valcannuta, 247, Rome I-00166, Italy;

关键词: marine drugs;    Alzheimer’s disease;    mechanisms of activity;    clinical/preclinical studies;    bryostatin;    new drugs;   

DOI  :  10.3390/md14010005

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and their respective new therapeutic targets in AD and other neurodegenerative disorders. In this review, selected examples of marine-derived compounds in neurodegeneration, specifically in AD field are reported. The emphasis has been done on compounds and their possible relevant biological activities. The proposed drug development paradigm and current hypotheses should be accurately investigated in the future of AD therapy directions although taking into account successful examples of such approach represented by Cytarabine, Trabectedin, Eribulin and Ziconotide. We review a complexity of the translational research for such a development of new therapies for AD. Bryostatin is a prominent candidate for the therapy of AD and other types of dementia in humans.

【 授权许可】

Unknown