Mitigative Effects of PFF-A Isolated from Ecklonia cava on Pigmentation in a Zebrafish Model and Melanogenesis in B16F10 Cells

Marine Drugs

卷:20

Jun-Ho Heo¹  Bo-Mi Ryu¹  Jun-Geon Je¹  You-Jin Jeon¹  Yunfei Jiang²  Xining Li³ 

[1]Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea

[2]|School of Food Engineering, Jilin Agriculture Science and Technology University, Jilin 132101, China

[3]|School of Life Sciences, Northeast Normal University, Changchun 130024, China

关键词: phlorofucofuroeckol-A;    Ecklonia cava;    melanogenesis;    B16F10 cell lines;    zebrafish;   

DOI  :  10.3390/md20020123

来源: DOAJ

【 摘 要 】

Melanin synthesis is a defense mechanism that prevents skin damage, but excessive accumulation of melanin occurs in the skin in various reactions such as pigmentation, lentigines, and freckles. Although anti-melanogenic effects have been demonstrated for various naturally occurring marine products that inhibit and control tyrosinase activity, most studies have not been extended to in vivo applications. Phlorofucofuroeckol-A (PFF-A, 12.5–100 µM) isolated from Ecklonia cava has previously been shown to have tyrosinase-mitigative effects in B16F10 cells, but it has not been evaluated in an in vivo model, and its underlying mechanism for anti-melanogenic effects has not been studied. In the present study, we evaluated the safety and efficacy of PFF-A for anti-melanogenic effects in an in vivo model. We selected low doses of PFF-A (1.5–15 nM) and investigated their mitigative effects on pigmentation stimulated by α-MSH in vivo and their related-mechanism in an in vitro model. The findings suggest that low-dose PFF-A derived from E. cava suppresses pigmentation in vivo and melanogenesis in vitro. Therefore, this study presents the possibility that PFF-A could be utilized as a new anti-melanogenic agent in the cosmeceutical industries.

【 授权许可】

Unknown