Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta

Biomedicines

卷:9

Leon Schurgers¹  Wouter Huberts²  Shaiv Parikh²  Bart Spronck²  Koen Reesink²  Tammo Delhaas²  Gijs Debeij³  Jos Maessen³  Ehsan Natour³  Elham Bidar³  Berta Ganizada³ 

[1] Department of Biochemistry, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands;

[2] Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands;

[3] Department of Cardiothoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands;

关键词: aortic aneurysm;    vascular biomechanics and mechanobiology;    tissue deformation;    image feature tracking;   

DOI  :  10.3390/biomedicines9060670

来源: DOAJ

【 摘 要 】

Local biaxial deformation measurements are essential for the in-depth investigation of tissue properties and remodeling of the ascending thoracic aorta, particularly in aneurysm formation. Current clinical imaging modalities pose limitations around the resolution and tracking of anatomical markers. We evaluated a new intra-operative video-based method to assess local biaxial strains of the ascending thoracic aorta. In 30 patients undergoing open-chest surgery, we obtained repeated biaxial strain measurements, at low- and high-pressure conditions. Precision was very acceptable, with coefficients of variation for biaxial strains remaining below 20%. With our four-marker arrangement, we were able to detect significant local differences in the longitudinal strain as well as in circumferential strain. Overall, the magnitude of strains we obtained (range: 0.02–0.05) was in line with previous reports using other modalities. The proposed method enables the assessment of local aortic biaxial strains and may enable new, clinically informed mechanistic studies using biomechanical modeling as well as mechanobiological profiling.

【 授权许可】

Unknown