International Journal of Molecular Sciences | |
The Potential Role of DNA Methylation in Abdominal Aortic Aneurysms | |
Evan J. Ryer2  Kaitryn E. Ronning3  Robert Erdman3  Charles M. Schworer3  James R. Elmore2  Thomas C. Peeler1  Christopher D. Nevius3  John H. Lillvis5  Robert P. Garvin2  David P. Franklin2  Helena Kuivaniemi3  Gerard Tromp3  Jonathan Golledge4  | |
[1] Department of Biology, Susquehanna University, Selinsgrove, PA 17870, USA; E-Mail:;Department of Vascular and Endovascular Surgery, Geisinger Health System, Danville, PA 17822, USA; E-Mails:;Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA 17822, USA; E-Mails:Department of Vascular and Endovascular Surgery, Geisinger Health System, Danville, PA 17822, USA;;Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48202, USA; E-Mail: | |
关键词: DNA methylation; AAA; KLHL35; CNN2; SERPINB9; ADCY10P1; aortic aneurysm; | |
DOI : 10.3390/ijms160511259 | |
来源: mdpi | |
【 摘 要 】
Abdominal aortic aneurysm (AAA) is a complex disorder that has a significant impact on the aging population. While both genetic and environmental risk factors have been implicated in AAA formation, the precise genetic markers involved and the factors influencing their expression remain an area of ongoing investigation. DNA methylation has been previously used to study gene silencing in other inflammatory disorders and since AAA has an extensive inflammatory component, we sought to examine the genome-wide DNA methylation profiles in mononuclear blood cells of AAA cases and matched non-AAA controls. To this end, we collected blood samples and isolated mononuclear cells for DNA and RNA extraction from four all male groups: AAA smokers (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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