Decreased CD8+ Lymphocytic Infiltration in Multifocal and Multicentric Glioblastomas

Frontiers in Oncology

卷:11

Liang Kan¹  Run Wang²  Yang Jiang³  Sheng Han⁴  Tianhao Hu⁴  Yifu Song⁴  Xiaoliang Wang⁴  Juanhan Yu⁵  Di Zhang⁵ 

[1] Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China;

[2] Department of Neurosurgery, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China;

[3] Department of Neurosurgery, Shanghai First People’s Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China;

[4] Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, China;

[5] Department of Pathology, China Medical University, Shenyang, China;

关键词: Multifocal glioma;    CD8;    tumor-infiltrating lymphocytes (TILs);    chemotherapy;    prognosis;   

DOI  :  10.3389/fonc.2021.748277

来源: DOAJ

【 摘 要 】

PurposeMultifocal and multicentric glioblastomas (mGBMs) are associated with a poorer prognosis compared to unifocal glioblastoma (uGBM). The presence of CD8+ tumor-infiltrating lymphocytes (TILs) is predictive of clinical outcomes in human malignancies. Here, we examined the CD8+ lymphocytic infiltration in mGBMs.MethodsThe clinical data of 57 consecutive IDH wildtype primary mGBM patients with histopathological diagnoses were retrospectively reviewed. CD8+ TILs were quantitatively evaluated by immunohistochemical staining. The survival function of CD8+ TILs was assessed by Kaplan–Meier analysis and Cox proportional hazard models.ResultsNo significant difference in the concentration of CD8+ TILs was observed among foci from the same patient (P>0.150). The presence of CD8+ TILs was similar between multifocal and multicentric GBMs (P=0.885). The concentration of CD8+ TILs was significantly lower in mGBMs than in uGBMs (P=0.002). In mGBM patients, the CD8+ TIL level was associated with preoperative KPS (P=0.018). The median overall survival (OS) of the 57 mGBMs was 9 months. A low CD8+ TIL level (multivariate HR 4.404, 95% CI 1.954-9.926, P=0.0004) was an independent predictor of poor OS, while postoperative temozolomide chemotherapy (multivariate HR 6.076, 95% CI 2.330-15.842, P=0.0002) was independently associated with prolonged OS in mGBMs.ConclusionsDecreased CD8+ TIL levels potentially correlate with unfavorable clinical outcome in mGBMs, suggesting an influence of the local immuno-microenvironment on the progression of mGBMs.

【 授权许可】

Unknown