The Tumor Microenvironment in Colorectal Cancer Therapy

Cancers

Francis Esposito¹  Joan Maurel¹  Leire Pedrosa¹  TimothyM. Thomson² 

[1] Department of Medical Oncology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain;Networking Center for Biomedical Research in Hepatic and Digestive Diseases (CIBER-EHD), Instituto de Salud Carlos III, 28029 Madrid, Spain;

关键词: colorectal cancer;    mCRC;    tumor microenvironment (TME);    tumor-infiltrating lymphocytes (TILs);    angiogenesis;    tumor metabolism;   

DOI  :  10.3390/cancers11081172

来源: DOAJ

【 摘 要 】

The current standard-of-care for metastatic colorectal cancer (mCRC) includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, even though the addition of anti-angiogenic agents to backbone chemotherapy provides little benefit for overall survival. Since the approval of anti-angiogenic monoclonal antibodies bevacizumab and aflibercept, for the management of mCRC over a decade ago, extensive efforts have been devoted to discovering predictive factors of the anti-angiogenic response, unsuccessfully. Recent evidence has suggested a potential correlation between angiogenesis and immune phenotypes associated with colorectal cancer. Here, we review evidence of interactions between tumor angiogenesis, the immune microenvironment, and metabolic reprogramming. More specifically, we will highlight such interactions as inferred from our novel immune-metabolic (IM) signature, which groups mCRC into three distinct clusters, namely inflamed-stromal-dependent (IM Cluster 1), inflamed-non stromal-dependent (IM Cluster 2), and non-inflamed or cold (IM Cluster 3), and discuss the merits of the IM classification as a guide to new immune-metabolic combinatorial therapeutic strategies in mCRC.

【 授权许可】

Unknown