Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea

Türk Oftalmoloji Dergisi

卷:46

Yonca Aydın Akova¹  İlkay Kılıç Müftüoğlu² 

[1] Bayındır Kavaklıdere Hospital, Ophthalmology Clinic, Ankara, Turkey;

[2] İstanbul Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey;

关键词: Ocular rosacea;    treatment;    complications;    cyclosporine;   

DOI  :  10.4274/tjo.48902

来源: DOAJ

【 摘 要 】

Objectives: To report the clinical features, treatment options and complications in patients with ocular rosacea.Materials and Methods: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocularsigns and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer’s testresults were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-termtopical corticosteroids, topical 0.05% cyclosporine and oral doxycycline treatment were applied as a standard therapy to all patients.Additional treatments were given as needed. Complications were recorded.Results: Twenty-four patients with a mean age of 48.5±35.4 (32-54) years were followed for a mean 15±9.4 (8-36) months. Ocularfindings included meibomitis in 100% of cases, anterior blepharitis in 83% (40 eyes), punctate keratopathy in 67% (32 eyes), chalaziain 50% (24 eyes), corneal neovascularization in 50% (24 eyes) and subepithelial infiltrates in 16.6% (8 eyes). Significant improvementof symptoms and clinical findings were achieved in all patients with treatment. The increases in Schirmer’s test and BUT were 3.3±1.5and 4.5±2.8, respectively (p<0.05). Descemetocele and small corneal perforation occurred in 2 eyes; re-epithelialization was achieved inboth eyes with tissue adhesive application (1 eye) and additional amniotic membrane transplantation (1 eye). Four eyes of three patientsshowed significant regression of corneal neovascularization with topical bevacizumab therapy.Conclusion: Ocular rosacea may present with a variety of ophthalmic signs. It is possible to control the ophthalmic disease withappropriate therapeutic modalities including topical corticosteroids, topical cyclosporine and systemic doxycycline.

【 授权许可】

Unknown