Protective Effect of Wheat and Barley Grass Against the Acute Toxicological Effects of the Concurrent Administration of Excessive Heavy Metals in Drinking Water on the Rats Liver and Brain

Applied Sciences

卷:11

Amina Zedan¹  Heba Elbasiouny¹  Medhat Rehan²  Diaa Abd El Moneim³  LamiaaM. Abd El-Maoula⁴  HananS.E. Eldamaty⁴  OlaIbrahim El-Desoky⁴  AmiraM. Elmoslemany⁴ 

[1] Department of Environmental and Biological Sciences, Home Economy Faculty, Al-Azhar University, Tanta 31732, Egypt;

[2] Department of Genetics, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt;

[3] Department of Plant Production (Genetic Branch), Faculty of Environmental and Agricultural Sciences, Arish University, El-Arish 45511, Egypt;

[4] Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, Egypt;

关键词: drinking water contamination;    heavy metals;    rat liver;    rat brain;    germinated wheat;    germinated barley;   

DOI  :  10.3390/app11115059

来源: DOAJ

【 摘 要 】

Heavy metal contaminated water is a great concern because of its high toxiciy, non-biodegradability, and bioaccumulation. Therefore, non-contaminated water is fundamental for a healthy life. Special attention is paid to the health-promoting ingredients of germinated whole cereal products. This study aimed to (1) examine the potentially harmful effects of Cu, Mn, and Zn on rat livers and brains, and (2) the potentially protective action of wheat and barley grasses against the expected harmful effects of these metals. The rats were treated with water contaminated by heavy metals (HMs) and germinated wheat and barley for 60 days. The rat liver functions and histopathological examinations were analyzed. Comet assay was evaluated to assess the damage in the DNA of rat livers and brains. The results indicated a significant alteration in liver functions in rats exposed to HMs; however, wheat and barley grasses at high doses decreased the harmful effects. An insignificant difference was noticed in total protein, albumin, and globulin of rats treated with HMs compared with the control. A significant increase in the serum and liver levels of HMs was recorded; however, they were reduced by wheat and barley grasses. Rat livers treated with HMs exhibited severe histological effects. The groups treated with wheat and barley grasses showed a normal liver architecture. A significant increase in DNA damage in the livers and brains was observed in rats treated with HMs, which was reduced when treated with wheat and barley grasses. Thus, using germinated seeds is promising to avoid damaging of HMs.

【 授权许可】

Unknown