Selectivity in multiple multicomponent reactions: types and synthetic applications

Beilstein Journal of Organic Chemistry

卷:15

Francesca Seghetti¹  Rodolfo Lavilla²  Ouldouz Ghashghaei² 

[1] Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Belmeloro, 6, 40126, Bologna, Italy;

[2] Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain;

关键词: isocyanides;    multicomponent reactions;    reaction discovery;    selectivity;   

DOI  :  10.3762/bjoc.15.46

来源: DOAJ

【 摘 要 】

Multiple multicomponent reactions reach an unparalleled level of connectivity, leading to highly complex adducts. Usually, only one type of transformation involving the same set of reactants takes place. However, in some occasions this is not the case. Selectivity issues then arise, and different scenarios are analyzed. The structural pattern of the reactants, the reaction design and the experimental conditions are the critical factors dictating selectivity in these processes.

【 授权许可】

Unknown