From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis

Microorganisms

卷:9

MariaJose Fabrega¹  Astrid Hart de Ruijter²  Marc Guell²  Bernhard Paetzold²  Miquel Rozas²  Francois Brillet²  Amine Zorgani² 

[1] Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), C. Dr. Aiguader 88, 08003 Barcelona, Spain;

[2] S-Biomedic, JLABS, Turnhoutseweg 30, 2340 Beerse, Belgium;

关键词: skin microbiota;    microbiome dysbiosis;    skin disorders;    Cutibacterium acnes;    topical bacteriotherapy;   

DOI  :  10.3390/microorganisms9030628

来源: DOAJ

【 摘 要 】

Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major role in local skin homeostasis. To assess the role of this bacterium in healthy skin, this review focused on (i) the abundance of C. acnes in the skin microbiome of healthy skin and skin disorders, (ii) its major contributions to human skin health, and (iii) skin commensals used as probiotics to alleviate skin disorders. The loss of C. acnes relative abundance and/or clonal diversity is frequently associated with skin disorders such as acne, atopic dermatitis, rosacea, and psoriasis. C. acnes, and the diversity of its clonal population, contributes actively to the normal biophysiological skin functions through, for example, lipid modulation, niche competition and oxidative stress mitigation. Compared to gut probiotics, limited dermatological studies have investigated skin probiotics with skin commensal strains, highlighting their unexplored potential.

【 授权许可】

Unknown