Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition

BMC Microbiology

卷:21

Zongcheng Yang¹  Yangheng Zhang²  Jingyuan Li³  Shaohua Ge³  Yundong Sun⁴  Ya Li⁴  Jihui Jia⁴  Shutong Li⁴  Wenjuan Li⁴  Huanjie Li⁵ 

[1] Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration;

[2] Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University;

[3] Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration;

[4] Key Laboratory for Experimental Teratology of Ministry of Education and Department of Microbiology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University;

[5] School of Medicine, Cheeloo College of Medicine, Shandong University;

关键词: Helicobacter pylori;    Oral lichen planus;    Saliva;    Microbiome;    Inflammatory factor;   

DOI  :  10.1186/s12866-021-02188-0

来源: DOAJ

【 摘 要 】

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Although Helicobacter pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection. Result In this study, saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-13-labeled urea breath test (UBT). The saliva samples were divided into the following four groups based on the H. pylori status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−). Oral microbiome compositions were significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, those in the OLP+ group had a higher incidence of erosive OLP and higher levels of salivary cytokines. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups. Conclusions This is the first report to demonstrate that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP.

【 授权许可】

Unknown