TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer

Bioengineered

卷:13

Xintian Chen¹  Sen Meng¹  Zhongwei Li¹  Pengfei Wang¹  Wenwen Wang¹  Jin Bai¹  Xueying Ji²  Youguo Chen³  Jieyun Sun³ 

[1] Cancer Institute, Xuzhou Medical University, Xuzhou, China;

[2] Department of Obstetrics and Gynecology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China;

[3] Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, China;

关键词: ovarian cancer;    TRIM21;    proliferation;    migration;   

DOI  :  10.1080/21655979.2022.2042134

来源: DOAJ

【 摘 要 】

Tripartite motif-containing 21 (TRIM21) has been reported to have a cancer-promoting or anticancer effect in various tumors; however, its role in ovarian cancer (OC) remains to be elucidated. In this study, we explored the biological function of TRIM21 in OC progression and investigated the potential mechanisms. We found that TRIM21 was remarkably decreased in OC tissues and cell lines compared with adjacent-cancerous tissues and normal ovarian epithelium cell. Decreased expression of TRIM21 in OC patients was significantly correlated with shorter overall and disease-specific survival by The Cancer Genome Atlas database (TCGA) analysis. Functional assays revealed that TRIM21 inhibited the migration and invasion of OC cells; and that TRIM21 also obviously impaired cell proliferation by inhibiting cell cycle progression in vitro and in vivo. Taken together, our results suggest that TRIM21 may be a promising biomarker and target for OC diagnosis and treatment.

【 授权许可】

Unknown